These materials were useful to study the Paleolithic age in Azerbaijan.
Pollen analysis conducted in Gazma Cave (Sharur District) suggests that humans in the Middle Palaeolithic (Mousterian) lived not only in the mountain forests but also in the dry woodlands found in Nakhchivan.
In the 16th century, control of Nakhchivan passed to the Safavid dynasty.
After the 1917 February Revolution, Nakhchivan and its surrounding region were under the authority of the Special Transcaucasian Committee of the Russian Provisional Government and subsequently of the short-lived Transcaucasian Democratic Federative Republic.
When the TDFR was dissolved in May 1918, Nakhchivan, Nagorno-Karabakh, Zangezur (today the Armenian province of Syunik), and Qazakh were heavily contested between the newly formed and short-lived states of the Democratic Republic of Armenia (DRA) and the Azerbaijan Democratic Republic (ADR).
According to the early medieval Armenian historian Movses Khorenatsi, from the 3rd to 2nd centuries, the region belonged to the Muratsyan nakharar family but after disputes with central power, King Artavazd I massacred the family and seized the lands and formally attached it to the kingdom. Nakhchivan is said by his pupil, Koriun Vardapet, to be the place where the Armenian scholar and theologian Mesrob Mashtots finished the creation of the Armenian Alphabet and opened the first Armenian schools.
According to the Armenian historian Faustus of Byzantium (5th century), when the Sassanid Persians invaded Armenia, Sassanid King Shapur II (310-380) removed 2,000 Armenian and 16,000 Jewish families in 360-370. It happened in the province of Gokhtan, which corresponds to Nakhchivan's modern Ordubad district.